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REV-ERB agonists as therapeutic agents for metabolic disorders

Engineered solely for preclinical investigations, each batch of Dihexa undergoes a comprehensive quality assessment and includes complete documentation, including a Certificate of Analysis (COA), purity data, and structural verification

Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M

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The outcome suggested that a transient and limited increase in gut permeability compared with the unregulated breach of the gut barrier function due to the TJ deregulation and epithelial cell apoptosis can rather lead to a dominant regulatory immune response to gut microbiota antigens and to a net anti-inflammatory effect